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EMERGENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AS AN IMPORTANT CAUSE OF NOSOCOMIAL INFECTIONS IN BURNS-ICU PATIENTS IN A TERTIARY CARE CENTRE. Anshuman Sikka, Dimple Kasana

EMERGENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AS AN IMPORTANT CAUSE OF NOSOCOMIAL INFECTIONS IN BURNS-ICU PATIENTS IN A TERTIARY CARE CENTRE.

Anshuman Sikka, Dimple Kasana

International Journal of Applied Microbiology Science 2012; 1(3):1-9


Abstract

Methicillin-resistant Staphylococcus aureus strains (MRSA) have become increasingly prevalent as nosocomial pathogens, especially in burn wounds. It is necessary to define the problem of MRSA in every hospital to evolve control strategies.
The present study was undertaken to study the incidence and resistance pattern of MRSA infection in burns-ICU patients at a tertiary care centre in India.
Study population was selected, based on inclusion criteria defined for the study. Appropriate samples were collected and were immediately transferred to microbiology department under all aseptic conditions. They were immediately processed as per the standard protocol. Antimicrobial susceptibility was performed by the standard disk diffusion method and MIC was determined by E-strips as recommended by Clinical & Laboratory Standard Institute (CLSI) guidelines.
Total 934 samples from 349 patients were analyzed. Staphylococcus aureus was isolated in total 34 samples (3.64%). Out of these 22 were MRSA (64.71%) as determined by cefoxitin and oxacillin discs. MRSA showed maximum sensitivity to Vancomycin (100%) followed by Clindamycin (31.82%), Erythromycin (4.54%). All were Penicillin resistant. Methicillin sensitive Staphylococcus aureus (MSSA) showed maximum sensitivity to Vancomycin (100%) and Clindamycin (100%), followed by Erythromycin (91.67%) and Penicillin (41.67%).
The presence of MRSA as well as increased antibiotics resistance in Burns ICU patients is alarming. Accurate and early detection of MRSA is of utmost importance to treat and to prevent their further transmission and also to reduce the morbidity and mortality among burns ICU patients.

Keywords: Nosocomial infection, Methicillin resistant Staphylococcus aureus
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