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IN-VITRO ANTIOXIDANT POTENTIAL STUDIES OF PLANT EXTRACT OF TINOSPORA CORDIFOLIA. Neetu Thakur, Nancy, Sakshi Chawla, R Pathak, A Pathak

IN-VITRO ANTIOXIDANT POTENTIAL STUDIES OF PLANT EXTRACT OF TINOSPORA CORDIFOLIA.

Neetu Thakur, Nancy, Sakshi Chawla, R Pathak, A Pathak

International Journal of Applied Microbiology Science 2012; 1; 15-20.

Abstract

Biomolecules can be oxidized by free radicals which results in oxidative stress. This oxidative damage has an important etiological role in aging and development of diseases like cancer, atherosclerosis, and other inflammatory disorders. Synthetic antioxidants, like butylated hydroxyanisole, are good free radical scavengers; however, the synthetic antioxidants can be carcinogenic. Therefore, there is an increasing interest in searching for antioxidants of natural origin. We report here the in vitro antioxidant activity of T. cordifolia extract used in traditional medicine for the treatment of several infectious and inflammatory diseases. Antioxidant activity was measured by means of in vitro enzymatic and non - enzymatic assays. The extract of T. cordifolia showed excellent in vitro antioxidant due to the presence of high phenolic (52.5 μg/mg) and vitamin C (0.102 mg/ml) content. The percent catalase inhibition in diabetic + plant extract was 88.4% which can be further raised up to 90.2 % in the zinc treated diabetic rat liver + plant extract. This may be due to the additional antiperoxidative potential of zinc. The present studies on in vitro antioxidant activities of Tinospora cordifolia justify the ethano- medical use of this plant.

Keywords In vitro, antioxidant studies, Tinospora cordifolia, diabetes, Zinc.
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