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NATURAL POLYMERS IN COLONIC DRUG DELIVERY. Poonam Kushwaha

NATURAL POLYMERS IN COLONIC DRUG DELIVERY.

Poonam Kushwaha

International Journal of Natural Product Science 2014; 4(1): 1-7

Abstract

Natural polysaccharides are now extensively used for the development of dosage forms for delivery of drug to the colon. The rationale for the development of a polysaccharide based delivery system for colon is the presence of large amounts of polysaccharidases in the human colon as the colon is inhabited by a large number and variety of bacteria which secrete many enzymes e.g. β-D-glucosidase, β-D-galactosidase, amylase, pectinase, xylanase, β-D-xylosidase, dextranase, etc. Various major approaches utilizing polysaccharides for colon-specific delivery are fermentable coating of the drug core, embedding of the drug in biodegradable matrix, formulation of drug-saccharide conjugate (prodrugs). A large number of polysaccharides have already been studied for their potential as colon-specific drug carrier systems, such as chitosan, pectin, chondroitin sulphate, cyclodextrin, dextrans, guar gum, inulin, amylose and locust bean gum. The purpose of this review is to discuss the use of such natural polysaccharides as colon-specific drug delivery system.

Keyword: Drug delivery, natural polymers, natural polysaccharides
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