HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

AMELIORATION OF CADMIUM INDUCED NEPHROTOXICITY IN BALB/c MICE BY WITHANIA SOMINIFERA AND VITAMIN E. Mani Chopra, Archana Sharma, Vijay Lakshmi Sharma

AMELIORATION OF CADMIUM INDUCED NEPHROTOXICITY IN BALB/c MICE BY WITHANIA SOMINIFERA AND VITAMIN E.

Mani Chopra, Archana Sharma, Vijay Lakshmi Sharma

International Journal of Natural Product Science 2013; 3(6): 9-19

Abstract

Cadmium (Cd) is considered as one of the most toxic transition metal elements that can cause severe damage to organ systems. Withania sominifera is an important Indian medicinal plant rich in bioactive and bio-available components like steroidals, alkaloids and lactones known as ‘withanolides’ while vitamin E is an important dietary component and is readily lipid soluble antioxidant of biological system. The present study investigated the ameliorating potential of Withania sominifera (500 mg/kg b.wt.) and vitamin E (100 mg/kg b.wt.) against Cd induced nephrotoxicity. Balb/c mice were injected with cadmium sulphate intraperitoneally (5mg/kg b.wt.) daily for 5 days and sacrificed. Five days cadmium exposure caused significant elevation in levels of lipid peroxidation (LPO), decreased antioxidant levels and marked structural alterations in renal tissue. Withania administration to cadmium treated mice showed signs of recovery but Withania and vitamin E concomitant treatment effectively inhibited LPO by enhancing the antioxidant enzyme activities and scavenging the reactive oxygen species (ROS) involved in the initiation of LPO and thus restored the histoarchitecture of mice kidneys. These results elucidate that Withania and vitamin E have plausible therapeutic implications against heavy metal owing to their anti-oxidant and antiperoxidative potentials.

Key words: Cadmium, kidneys, vitamin E, Withania somnifera
Attachments:
Time to create page: 0.13 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com