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HYPOGLYCEMIC EFFECT OF BLACK TEA POLYPHENOLS WITH HERBS IN EXPERIMENTAL ANIMALS. Latha K, Anitha GR, Gnana Poongothai S

HYPOGLYCEMIC EFFECT OF BLACK TEA POLYPHENOLS WITH HERBS IN EXPERIMENTAL ANIMALS.

Latha K, Anitha GR, Gnana Poongothai S

International Journal of Natural Product Science 2012; 2(2): 15-28.

Abstract

The anti-hyperglycemic activity of black tea amalgamated with herbs that are well established for their therapeutic properties was studied to exploit its use as a daily cup of tea in the treatment of Diabetes mellitus in humans. The extract at a dose of 500mg/kg/b.w reduced the FBG levels by 44.91% and showed improvement in glucose tolerance. The results of this study show the ability of the herbs in combination with tea to prevent the elevation of serum and tissue lipids secondary to the diabetes condition. Dosage at three levels (250 mg/kg, 500mg/kg, 1g/kg), indicate that the hypo-lipidemic effect was evident at 500mg /kg, with no significant alteration at higher dose. The lowering of the enhanced levels of triglycerides was significant with herbal tea (125mg/dl) compared to the plain tea (161mg/dl). Excess levels of fatty acids was observed in the untreated diabetic group compared to the diabetic plain tea treated group. Elevated levels of lipid peroxidation products was found in the tissues of the untreated diabetic group along with low activities of the antioxidant enzymes like SOD and glutathione peroxidase.

Key words: Black tea (Camellia sinensis), Hyperglycemia, lipid profile, antioxidant enzymes.
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