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STUDY ON SYNTHESIS OF NOVEL AZAFLAVANONE. Appramdeep Kaur, N.S.Gill, R.Arora

STUDY ON SYNTHESIS OF NOVEL AZAFLAVANONE.

Appramdeep Kaur, N.S.Gill, R.Arora

International Journal of Natural Product Science 2012: Spl Issue 1:249.

Abstract(RBIP-249)

The flavonoids are polyphenolic substances which are integral component of human diet. These are low molecular weight compounds that are widely distributed in plant kingdom. Because of wide range of biological properties, flavanoids and its derivatives is becoming the subject of medical research. They have been reported to possess anti-inflammatory activity, oestrogenic, enzyme inhibition, antimicrobial, antiallergic, antioxidant, vascular, cytotoxic and antitumor activity. Some of the best food sources of flavonoids are red wine, apples, blueberries, bilberries, onions, soy products and tea. These are divided into various classes, of which flavanone is one class. When oxygen of flavanone is replaced by nitrogen then that are called ‘Azaflavanone’ (basic ring system of quinolones). Azaflavonones consist of a large number of pharmacological activities.

The aim of the present work is to synthesize azaflavanone using 2-amino acetophnone by Claisen-Schmidt reaction. In first step, 2-amino acetophenone was acetylated using acetic anhydride and confirmed by thin layer chromatography and melting point. Then it was preceded to synthesize open chain chalcone by condensing it with benzaldehyde. In last step, open chain ring will be closed and confirmed by thin layer chromatography, FTIR, 1H NMR. Various Azaflavanone derivatives will be synthesized using substituted benzaldehydes.
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