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DRUG DISCOVERY AND DEVELOPMENT. Arshdeep Kaur, Mandeep Kaur, Komalpreet Kaur, Ramninder Kaur

DRUG DISCOVERY AND DEVELOPMENT.

Arshdeep Kaur, Mandeep Kaur, Komalpreet Kaur, Ramninder Kaur

International Journal of Natural Product Science 2012: Spl Issue 1:242.

Abstract(RBIP-242)

Drug discovery process is a critical issue in the pharmaceutical industry since it is a very cost-effective and time consuming process to produce new drug potentials and enlarge the scope of diseases incurred. Drug target identification, being the first phase in drug discovery is becoming an overly time consuming process. Drug discovery process operates on a target-based approach, in which the organism is seen as a series of genes and pathways and the goal is to develop drugs that affect only one gene or molecular mechanism in order to selectively treat the deficit causing the disease without producing side effects. The stages of modern drug discovery process pipeline to find out the new drugs. Modern drug discovery process pipeline consists of seven important steps: target identification, target validation, hit and lead identification, lead optimization, pre clinical testing, chemical testing and new drug application (NDA) and food and drug administration (FDA) approval. The process of drug discovery involves the identification of candidates, synthesis, characterization, screening and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.

Key Words: Drug Discovery, Drug Development.
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