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SMEDDS: A NOVEL APPROACH FOR BIOAVAILABILITY ENHANCEMENT OF HYDROPHOBIC DRUGS. Vikas Sharma, Bhawandeep Gill, S.L.Hari Kumar

SMEDDS: A NOVEL APPROACH FOR BIOAVAILABILITY ENHANCEMENT OF HYDROPHOBIC DRUGS.

Vikas Sharma, Bhawandeep Gill, S.L.Hari Kumar

International Journal of Natural Product Science 2012: Spl Issue 1:237.

Abstract(RBIP-237)

The oral delivery of hydrophobic drugs shows major confront due to low aqueous solubility and lesser bioavailability. Self-micro emulsifying drug delivery systems (SMEDDSs) have gained revelation for their capability to increase solubility and bioavailability. SMEDDS are precisely defined as isotropic mixtures of oils, surfactants, solvents and co-solvents can be used for the designing formulations in order to improve the oral absorption of lipophilic drugs. SMEDDS can be orally administered and form fine relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to gentle agitation of the gastrointestinal fluids. The efficiency of absorption of drug from the SMEDDS depends on many parameters, as surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge, all of which determine the self-emulsification ability. Thus, only specific pharmaceutical excipient combinations will lead to efficient self-micro emulsifying systems. Although many studies have been carried out, there are few formulations in market formulated as SMEDDS confirming the difficulty of formulating hydrophobic drugs into such formulations. Almost 40% of the new drug compounds are hydrophobic in nature implies that studies with SMEDDS will continue, and more drug formulated as SMEDDS will reach pharmaceutical market in future.
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