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BIODEGRADABLE MICROSPHERES FOR PROTEIN DELIVERY. Vipin Saini, Rattan Lal, Deepti Pandita

BIODEGRADABLE MICROSPHERES FOR PROTEIN DELIVERY.

Vipin Saini, Rattan Lal, Deepti Pandita

International Journal of Natural Product Science 2012: Spl Issue 1:236.

Abstract(RBIP-236)

The rapid advances in synthesis of peptide and protein compounds for therapeutic activity have fueled enormous interest in developing microparticles based drug delivery using biodegradable polymers. A key factor in the design of injectable protein delivery systems is the choice of an appropriate biodegradable polymer. The concept of biodegradable polymers for sustained release of parentral drug delivery systems began to develop in early 1970s because of two reasons: firstly, surgical removal of drug-depleted delivery systems of non-biodegradable polymers is difficult and non-removal may pose toxicological problems; secondly, diffusion-controlled delivery systems, although excellent means of achieving predetermined rates of drug delivery, are limited by polymer permeability and drug characteristics. Biodegradable polymers, either synthetic or natural, are capable of being cleaved into biocompatible by-products through chemical or enzyme catalyzed hydrolysis. In systemic delivery of proteins; biodegradable microspheres as parenteral depot formulation occupy an important place because of several aspects like protection of sensitive proteins from degradation, prolonged or modified release /pulsatile release patterns. Biodegradable polymer microspheres delivery systems offer a lot of advantages in chemotherapy where they provided localized sustained release and reduced toxicity at the same time, since the drug can be localized by direct injection of drug-loaded-microspheres into tumor tissues, thus minimizing negative effect to the healthy tissues. Presently only a countable number of formulations based on such systems are available in the market. So far, biodegradable polymers particularly of PLGA type have been used, considering their well known degradation properties. An area requiring additional efforts is analytical characterization of protein microspheres. Although many advances have been made, much work still remains before proteins can be tamed as useful molecules for efficient drug delivery systems.
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