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RESEALED MAGNETIC ERYTHROCYTES: OR CANCER THERAPY. Shailly and Deepti Pandita

RESEALED MAGNETIC ERYTHROCYTES: OR CANCER THERAPY.

Shailly and Deepti Pandita

International Journal of Natural Product Science 2012: Spl Issue 1:235.

Abstract(RBIP-235)

Drug delivery is now entering quite an exciting and challenging era. Significant high costs involved in the development of new drug molecule has compelled scientists all over the world to search for alternative ways of administering the existing drug molecules with enhanced effectiveness. Among the various drug carriers investigated, the erythrocytes have found to possess greater potential in drug delivery because of its biocompatibility, biodegradability and long life span. Magnetic erythrocytes might be an admirable alternative in cytotoxic chemotherapy of cancer that is otherwise limited by serious, or sometimes life-threatening, side effects that arise from toxicities to sensitive normal cells as the conventional therapies are not selective for malignant cells. Recently, the researchers have developed a new drug delivery system based on magnetic erythrocytes engineered with a viral spike fusion protein. The new erythrocyte-based drug delivery system has the potential for magnetic-controlled site-specific localization and highly efficient fusion capability with the targeted cells. For example, the erythro-magneto-HA virosomes drug delivery system is able to attach and fuse with the target cells and to efficiently release therapeutic compounds inside the cells such that the efficacy of the anti-cancer drug employed is increased. Resealed magnetic erythrocytes have excellent potential for cancer therapy and these systems further needs to be investigated clinically as biological carriers of therapeutic agents.
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