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MESENCHYMAL STEM CELLS: A PROMISING TARGETED DELIVERY IN CANCER GENE THERAPY. Kanika Kaushik and Deepti Pandita

MESENCHYMAL STEM CELLS: A PROMISING TARGETED DELIVERY IN CANCER GENE THERAPY.

Kanika Kaushik and Deepti Pandita

International Journal of Natural Product Science 2012: Spl Issue 1:234.

Abstract(RBIP-234)

The targeting drug delivery systems have attracted extensive attention of researchers in recent years. More and more drug/gene targeted delivery carriers, such as liposome, magnetic nanoparticles, ligand conjugated nanoparticles etc. have been developed for anticancer agents to enhance their therapeutic values. Cell-based therapies are emerging as a promising therapeutic option for cancer treatment. Mesenchymal stem cells (MSCs) have been attractive cell therapy vehicles for the delivery of agents into tumor cells because of their capability of self-renewal, relative ease of isolation and expansion in vitro, and the ability to migrate towards and engraft into the tumor sites, which make them a great hope for efficient targeted delivery vehicles in cancer gene therapy. After transfecting MSCs with tumor therapeutic gene, the MSCs would deliver the gene towards tumor sites, which could be widely used in tumor therapy. Besides, recent evidence also suggests that MSCs selectively migrate to areas of injury/inflammation, where they are involved in the tissue repair. This effect makes MSCs as attractive candidates of widely used delivery vehicles for site-specific therapy. The tumour-homing capacity of mesenchymal stem cells may be manipulated by pre-programming the MSCs to alter their properties during the gene delivery process to increase their applicability as tumor-targeted cell delivery vehicles. Still, much work remains to be done before the clinical application of MSCs-based therapy. Moreover, the further development of these strategies could be extended by using various genes to achieve a general cell-based gene therapy platform for the treatment of different disease.
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