HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

PHARMACOLOGICAL EVALUATION OF BIOACTIVE PRINCIPLE OF PULSATILLA NIGRICANS STOERCK. ARSHDEEP KAUR, SANDEEP GOYAL AND SURESH KUMAR

PHARMACOLOGICAL EVALUATION OF BIOACTIVE PRINCIPLE OF PULSATILLA NIGRICANS STOERCK.

ARSHDEEP KAUR, SANDEEP GOYAL AND SURESH KUMAR

International Journal of Natural Product Science 2012: Spl Issue 1:230.

Abstract(RBIP-230)

In present investigation, pharmacological evaluation of quercetin, a bioactive principle of Pulsatilla nigricans Stoerck (Ranunculaceae), was carried out. Quercetin was evaluated for antianxiety activity at a dose of 10 mg/kg using well established models of anxiety, i.e., hole board test, light/dark test and mirrored chamber test. Quercetin significantly increased head dipping in hole board test. Further, quercetin increased latency to leave light zone and the time spent in light compartment of light/dark model of anxiety. The compound also decreased the latency time to enter the mirrored chamber, and increased the total time spent/number of entries in the mirrored chamber with respect to control. At a higher dose (about 5 fold the anxiolytic dose), quercetin showed mild sedative activity in actophotometer as it decreased activity scores. The results were statistically significant to that of control group but not comparable to diazepam (10 mg/kg). Quercetin exhibited mild anticonvulsant activity in MES-induced convulsion test at 50 mg/kg, p.o. Quercetin was also found to exhibit significant antidepressant and antistress activity in despair swim test and cold swimming test, respectively, at a dose of 10 mg/kg, p.o. In tail immersion test for six hours, quercetin exhibited significant analgesic activity at a dose of 100 mg/kg, which was comparable to that of morphine sulphate (5 mg/kg). The activity remained significant up to fourth hour of study in a manner similar to that shown by morphine sulphate. At sixth hour, analgesic activity decreased which might be due to metabolism of quercetin. In carrageenan induced paw edema test for three hours, quercetin exhibited anti-inflammatory activity at a dose of 100 mg/kg, which was comparable to that of indomethacin (10 mg/kg). Maximum activity was observed 1 h after the administration of 100 mg/kg dose of quercetin, and activity remained significant up to third hour of study in a manner similar to that shown by indomethacin. The present investigations validate the traditional use of P. nigricans in CNS related diseases due to presence of a bioactive flavonoid quercetin.

Keywords: Analgesic, Antianxiety, Anti-inflammatory, Pulsatilla nigricans, Sedative
Attachments:
Time to create page: 0.15 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com