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ANTIARTHRITIC ACTIVITY OF THE VARIOUS EXTRACT OF PLUMERIA ALBA LINN. IN ADJUVANT INDUCED ARTHRITIS IN MICE. Sandeep Tripathi. Vaibhav Gupta, Manjusha Choudhary, Vijay Naresh

ANTIARTHRITIC ACTIVITY OF THE VARIOUS EXTRACT OF PLUMERIA ALBA LINN. IN ADJUVANT INDUCED ARTHRITIS IN MICE.

Sandeep Tripathi. Vaibhav Gupta, Manjusha Choudhary, Vijay Naresh

International Journal of Natural Product Science 2012: Spl Issue 1:229.

Abstract(RBIP-229)

Leaf extracts of Plumeria alba Linn. (Apocynaceae) is commonly used by Madhya Pradesh folk tribe in their traditional medicine for the treatment of several pathological states including inflammatory disorders. The present study was undertaken to evaluate the antiarthritic effect of an ethanolic leaves extract and stem bark extract of P. alba in the therapeutic model of adjuvant induced arthritis in mice. Dexamethasone showed significant dose-dependent antiarthritic properties when applied to established adjuvant arthritis. Oral administration of both extract in doses 125,250 and 500 mg/Kg p.o. significantly reduced the arthritic edema in the lateral paw of mice with a maximal inhibition at 500mg/ kg dose. It also significantly prevented the spread of the edema from the lateral to the contralateral paws indicating inhibition of systemic spread. The steroidal anti-inflammatory agent dexamethasone (0.1 mg/kg i.p.) also reduced very significantly the total polyarthritic edema as well as the spread of the arthritis from the lateral to the contralateral paws of the treated animals. These results suggest that ethanolic extract of the stem bark and leaves of P.alba exerts antiarthritic activity after oral administration.

Keywords: Plumeria alba, Formaldehyde induced arthritis (FIA), Leaves extract (LE), Stem bark extract (SBE), Per oral (p.o).
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