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PHARMACOGENOMICS: ADVANCING TOWARDS PERSONALIZED DRUG THERAPY. Rajbir Bhatti and Rajinder Singh

PHARMACOGENOMICS: ADVANCING TOWARDS PERSONALIZED DRUG THERAPY.

Rajbir Bhatti and Rajinder Singh

International Journal of Natural Product Science 2012: Spl Issue 1:216.

Abstract(RBIP-216)

Pharmacogenomics deals with the genetic variation in drug response. With the success of human genome project, this branch of science has witnessed a renewed interest. Although differences in individual’s response to drugs had been evident much earlier, the new and improved techniques at our disposal currently can go a long way in studying individual variations and hence dispensing drugs. There is growing body of literature that reports the African Americans to be more responsive to antihypertensive therapy with furosemide and hydrochlorthiazide while they are less responsive to the beta blockers and the ACE inhibitors than the Caucasian races. Many other such instances are known. Diabetes mellitus encompasses chronic metabolic derangements and oxidant stress is responsible for accelerating the morbid outcomes of the syndrome. The haptoglobulin variants are presently being studied for individual variations in developing oxidant stress and cardiovascular events. Therefore pharmacogenomics can revolutionize modern drug therapy with the development of drugs meeting the individual’s needs based on their genotype or in other words personalized drug therapy.
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