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PRECLINICAL STUDY TO ASSESS EFFICACY AND SAFETY OF COMMONLY USED ANTIDEPRESSANTS FOR EPILEPSY INDUCED DEPRESSIVE BEHAVIOR. Rakesh Kumar Sharma, Awanish Mishra and Rajesh Kumar Goel

PRECLINICAL STUDY TO ASSESS EFFICACY AND SAFETY OF COMMONLY USED ANTIDEPRESSANTS FOR EPILEPSY INDUCED DEPRESSIVE BEHAVIOR.

Rakesh Kumar Sharma, Awanish Mishra and Rajesh Kumar Goel

International Journal of Natural Product Science 2012: Spl Issue 1:212.

Abstract(RBIP-212)

Depression is a common comorbid condition in patients with epilepsy (PWE), with a higher prevalence rate and negatively affects the quality of life. PWE are at higher risk of suicide as compared with the general population. Depression in PWE often remains undiagnosed and undertreated. Even when depression is recognized, it is left untreated due to fear of drug-drug interactions and exacerbation of seizure activity by the antidepressant medication. Therefore this study was envisaged to evaluate the efficacy and safety of most conventional clinically used antidepressant drugs on kindling induced depressive behavior. Male Swiss Albino mice were kindled with subconvulsive dose of pentylenetetrazol (35 mg/kg, i.p. at 48 ± 2 h intervals). Successfully kindled animals were used in the study to observe the effect of different antidepressant treatment; imipramine (20 mg/kg), fluoxetine (20 mg/kg), venlafaxine (10 mg/kg) and mirtazepine (10 mg/kg) i.p. OD for 15 days. The animals were challenged with pentylenetetrazol (35 mg/kg, i.p.) on day 5, 10 and 15 and seizure severity score, immobility period, in tail suspension test and forced swim test, were recorded. On 15th day, all the animals were sacrificed after behavioral evaluations and brain was isolated and homogenized to estimate brain serotonin, norepinephrine, total nitrite/nitrate level. Although, the treatment with all antidepressants ameliorated the depressive behavior associated with epilepsy, venlafaxine and mirtazapine treatment raised seizure threshold and decreased seizure severity in kindled animals, suggesting their safer clinical use for the treatment of epilepsy induced depressive behavior.
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