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AMELIORATIVE EFFECT OF CURCUMIN ON EPILEPSY AND ITS ASSOCIATED DEPRESSION IN POST KINDLED MICE. Kailash M. Choudhary, Damanpreet Singh, Awanish Mishra and Rajesh Kumar Goel

AMELIORATIVE EFFECT OF CURCUMIN ON EPILEPSY AND ITS ASSOCIATED DEPRESSION IN POST KINDLED MICE.

Kailash M. Choudhary, Damanpreet Singh, Awanish Mishra and Rajesh Kumar Goel

International Journal of Natural Product Science 2012: Spl Issue 1:211.

Abstract(RBIP-211)

Epilepsy is a chronic neurological disorder characterized by episodic and unpredictable incidence of epileptic seizures. It is commonly associated with the brain dysfunctions leading to several behavioral co morbidities like, depressive disorders (DDs). The present study was envisaged to evaluate the ameliorative effect of cur cumin a polyphenolic compound derived from Curcuma longa L on depression in post kindled animals. Male Swiss Albino mice were kindled by administering repeated subconvulsive doses of pentylenetetrazol (35 mg/kg; i.p.). Once kindled, the animals in different groups received vehicle or cur cumin (50, 100 and 200 mg/kg) for 15 days. The animals were challenged with pentylenetetrazol (35 mg/kg, i.p.) on every 5th day after kindling and seizure severity score and immobility period using forced swim test were recorded. On 15th day, all the animals were sacrificed after behavioral evaluations and the brain was isolated and homogenized to estimate brain serotonin, nor epinephrine and total nitrite/nitrate level. Cur cumin significantly attenuated seizure severity and depressive behavior indicated by decrease in the immobility period in post kindled animals. These results were evidenced by the biochemical modulation of the brain monoamine and nitrosamine stress levels. Thus, the present study concluded that cur cumin has curative potential for the management for epilepsy and depression in post kindled state, possibly via central monoaminergic modulation and inhibitory effect on nitrosative stress.
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