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PROTECTIVE ROLE OF BEE PROPOLIS AGAINST- NEUROFIBROMETOSIS. Nidhika, Pooja Sharma, Dinesh Kumar, Harwinder Singh Rao

PROTECTIVE ROLE OF BEE PROPOLIS AGAINST- NEUROFIBROMETOSIS.

Nidhika, Pooja Sharma, Dinesh Kumar, Harwinder Singh Rao

International Journal of Natural Product Science 2012: Spl Issue 1:200.

Abstract(RBIP-200)

Neurofibromatosis (NF) is defined by tumors called neurofibromas, that grow along the nerves in the body or under the skin. As the tumors increase in size, they can press on vital areas of the body, causing problem in the way body functions. Neurofibromatosis often first appears in childhood, especially during puberty. The first noticeable sign is always the presence of brown spots. Neurofibromatosis affects 1 in every 3000 people. . The body processes that form neurofibromatosis tumors are responsible for about 70% of human cancers. BEE PROPOLIS- Propolis is a natural resin found in young tree buds. Bees collect it for use as a glue to seal their homes. Propolis is an exceedingly complex product that contains substances that prevent and treat diseases ranging from cancer to the common cold. Propolis has ability to suppress the growth of human tumors from neurofibromatosis and cancer. Since bee propolis contain anti cancer ingredients caffeic acid phenethyl ester (CAPE) and artepillin C (ARC) which blocks the oncogenic PAK1 signaling pathways. It was demonstrated that the CAPE rich extract of propolis mixed with the water completely suppressed the growth of NF1. CAPE is a natural compound found in some foods, but is highly concentrated in bee propolis.
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