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DIFERRENT ANGIOTENSIN II RECEPTOR BLOCKER- EPROSARTAN. Nikhil T. Sahu, Harwinder Singh Rao, Shipra Sabherwal, Rajat Bhatia

DIFERRENT ANGIOTENSIN II RECEPTOR BLOCKER- EPROSARTAN.

Nikhil T. Sahu, Harwinder Singh Rao, Shipra Sabherwal, Rajat Bhatia

International Journal of Natural Product Science 2012: Spl Issue 1:193.

Abstract(RBIP-193)

The goal of antihypertensive treatment is to reduce risk of cardiovascular morbidity and mortality. Apart from blood pressure lowering per se, also reducing the activities of the renin-angiotensin system and sympathetic nervous system appears to be important. Angiotensin II receptor blocker drugs (ARBs) have provided a useful class of anti-hypertensive drugs. Eprosartan is a relatively new ARB which is chemically distinct (non-biphenyl, non-tetrazole) from all other ARBs (biphenyl tetrazoles). An analysis has been made on available experimental and clinical data on eprosartan which not only is an effective and well tolerated antihypertensive agent, but also lowers the activities of the renin-angiotensin system and sympathetic nervous system. Experimental and pharmacokinetic studies on eprosartan have shown differences with the other ARBs. The distinct properties of this non-biphenyl, non-tetrazole ARB might be relevant in the effort to reduce cardiovascular risk, also beyond its blood pressure lowering capacity. The antagonistic properties of eprosartan on the angiotensin II receptor type 1 (AT1) have been extensively documented. Unlike most other ARBs, which show noncompetitive kinetics, eprosartan is a pure competitive antagonist. Based on the absence of a direct comparison of eprosartan with other ARBs, the clinical relevance of the difference in chemical structure and kinetics has to be judged as unclear.
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