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NEUROPATHIC PAIN: A REVIEW. Samridhi Sharma, Jasneet Kaur, Jatinderjot Kaur Kehal

NEUROPATHIC PAIN: A REVIEW.

Samridhi Sharma, Jasneet Kaur, Jatinderjot Kaur Kehal

International Journal of Natural Product Science 2012: Spl Issue 1:186.

Abstract(RBIP-186)

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Pain can be Nociceptive Pain (Acute) or Neuropathic Pain (Chronic). Neuropathic Pain is the pain resulting from disease or damage of the peripheral or central nervous system, and from the dysfunction of the nervous system. Neuropathic Pain can be experienced as allodynia and hyperalgesia. The causes of Neuropathic Pain may be peripheral or central. The peripheral causes may be mononeuropathies, multiple mononeuropathies and polyneuropathies. The central causes may be due to tumour of spinal root/ dorsal root ganglion, brain stem, thalamus. Pain may be caused due to mediators like Substance P, Histamine, Prostaglandins, Bradykinin, Cytokines, Leukotrienes, and Serotonin etc. The currently used medicines for the treatment of Neuropathic Pain are Amitriptyline/ Nortriptyline and Gabapentin that belong to the class of tricyclic antidepressants and epilepsy. But due to the multifactorial causes of Neuropathic Pain these drugs are not so much responsive. Also, they are associated with a number of adverse effects like blood and hepatic disorders. So research is being done for the new drugs which can have the ability to ameliorate the causes and symptoms of Neuropathic Pain but with lesser/ few adverse effects.
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