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ANTIANXIETY ACTIVITY STUDIES OF PULSATILLA NIGRICANS STOERCK. Shaveta, Sandeep Kumar Goyal, Suresh Kumar and Sanjiv Mittal

ANTIANXIETY ACTIVITY STUDIES OF PULSATILLA NIGRICANS STOERCK.

Shaveta, Sandeep Kumar Goyal, Suresh Kumar and Sanjiv Mittal

International Journal of Natural Product Science 2012: Spl Issue 1:180.

Abstract(RBIP-180)

A rapid emergence of mental disorders has attracted the attention of researchers towards the plants, especially those that have been used traditionally to cure various ailments. Pulsatilla nigricans Stoerck is one among such plants, which has been used in various oriental systems of therapy. Though Pulsatilla nigricans is traditionally reputed for the treatment of CNS disorders, yet, the plant has not ever been subjected to systematic biological investigation. Thus, Pulsatilla nigricans was subjected to preliminary anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic. In the present investigation, aerial parts of the plant were extracted using solvents in order of increasing polarity viz., petroleum ether (60-80C), chloroform, methanol and distilled water. All the crude extracts were evaluated for anti-anxiety activity in mice using elevated plus maze apparatus. Among all these extracts, only methanol extract exhibited significant anti-anxiety activity at a dose of 200 mg/kg in mice with respect to control as well as standard (diazepam, 2 mg/kg). Phytochemical studies showed presence of flavonoids in bioactive methanol extract. Thus, flavonoids or alkaloids might be responsible for anxiolytic activity of Pulsatilla nigricans.
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