HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

PHARMACOGNOSTIC AND SCREENING STUDIES OF Centaurea behan Linn. Balbir Singh, Nondita Prasad, Pritpal Kaur, Shabnampreet kaur

PHARMACOGNOSTIC AND SCREENING STUDIES OF Centaurea behan Linn.

Balbir Singh, Nondita Prasad, Pritpal Kaur, Shabnampreet kaur

International Journal of Natural Product Science 2012: Spl Issue 1:179.

Abstract(RBIP-179)

Centaurea behan Linn. belongs to family Asteraceae which is commonly known as Safed Bahman in Hindi. Traditionally it was used as aphrodisiac, remedy of jaundice and in strengthening CNS system. Pharmacologically it is used as remedy for stones and in various herbal formulations to cure sexual disorders. The present studies were undertaken with an objective to evaluate pharmacognostic standards viz. organoleptic, microscopic, physicochemical parameters, phytochemical investigations and screening of various crude extracts viz. petroleum ether (PE), chloroform (CE), ethanolic (EE) and water (WE) for anticonvulsant activity. Microscopic studies revealed the presence of wide secondary phloem zone and thick solid, dense cylinder of secondary xylem. Secondary phloem has wide, dilated funnel shaped phloem, rays and conical segments of secondary phloem elements. Powder showed calcium oxalate crystals of different shapes i.e. of rhomboid, prismatic with different dimensions ranging from 30 µm to 10 µm. Result of physicochemical parameters showed that total ash was 16.44 % w/w, acid insoluble ash 11.74 % w/w and water-soluble ash 5.09% w/w, respectively. Further, water had a maximum extractable value of 9.6% followed by ethanol 2.6% and moisture content was found to be 7%. Phytochemical screening showed the presence of saponins, steroids and alkaloids. The aqueous extractive only exhibits the anticonvulsant effect. In the MES-induced convulsion model, lower doses 125 mg/kg and 250 mg/kg did not show any anticonvulsant effect against electroshock induced convulsions. Phenytoin at the dose of 25 mg/kg had prevented 100% extensor convulsions (Standard). The aqueous extract with the dose of 500 mg/kg reduced the duration of extensor phase but the results were not significant. The dose of 1 g/kg showed the most significant results as it reduced the extensor phase comparable to the standard dose of phenytoin.
Attachments:
Time to create page: 0.14 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com