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‘HIGH THROUGHPUT SCREENING AS AN URGE FOR PHARMACEUTICAL INDUSTRY’. Shehraj kaur, Kawalpreet kaur, Pooja Sharma,Dinesh Kumar, Harwinder Singh Rao

‘HIGH THROUGHPUT SCREENING AS AN URGE FOR PHARMACEUTICAL INDUSTRY’.

Shehraj kaur, Kawalpreet kaur, Pooja Sharma,Dinesh Kumar, Harwinder Singh Rao

International Journal of Natural Product Science 2012: Spl Issue 1:162.

Abstract(RBIP-162)

The ‘High Throughput Screening (HTS)’ process is the principle strategy for the discovery of new lead chemicals in the pharmaceutical industry. HTS uses miniaturized assay formats, usually microtitre plates in which 384 different samples can be assayed, at least than 50microlitre total assay volume, in one run. In order to discover new medicines which offer significant advantages over existing therapies, a key starting point is to identify novel biological targets that have a critical role in controlling disease processes. It involves creating biological assays capable of detecting substances which can modify the activity of the target. Theses ‘lead chemicals’ are compounds which are amenable to chemical manipulation in order to optimize their bioactivity and bioavailability profile. HTS is often portrayed by people who know little about it as an activity requiring very little intellectual input. The reality is that HTS is a complex process which demands an understanding role of specific biological targets in disease progression, the development of bioassays capable of discovering modulators of the target, the design, miniaturization and automation of bioassays which are automation friendly, an understanding of the macro- and micro- structure of the biological target so that the sample selection strategy is optimized.
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