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ANTI-INFLAMMATORY ACTIVITY OF TRADITIONAL MEDICINAL HERBS. Priyanka Thakur, Neetu Jamwal, Sunil Kumar, A.C. Rana, Dinesh Kumar

ANTI-INFLAMMATORY ACTIVITY OF TRADITIONAL MEDICINAL HERBS.

Priyanka Thakur, Neetu Jamwal, Sunil Kumar, A.C. Rana, Dinesh Kumar

International Journal of Natural Product Science 2012: Spl Issue 1:157.

Abstract(RBIP-157)

Accumulating epidemiological and clinical evidence shows that inflammation is an important risk factor for various human diseases. Thus, suppressing chronic inflammation has the potential to delay, prevent, and control various chronic diseases, including cerebrovascular, cardiovascular, joint, skin, pulmonary, blood, lymph, liver, pancreatic, and intestinal diseases. Various natural products from traditional medicine (TM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. Some studies have demonstrated that anti-inflammatory effects of TM occur by inhibition of the expression of master transcription factors (for example, nuclear factor-κB (NF-κ), pro-inflammatory cytokines (for example, tumor necrosis factor-α (TNF-α), chemokines (for example, chemokine (C-C motif) ligand (CCL)-24), intercellular adhesion molecule expression and pro-inflammatory mediators (for example, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2)). In this review, we summarize recent research attempting to identify the anti-inflammatory activity of TM and their mechanism of action that may create new opportunities for innovation in modern pharmacology. This review will pave a way to isolate and focus on traditional medicines.

Key words: Anti-inflammatory, Traditional medicines, Inflammation
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