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FLAVONOIDS AS PROMISING ANTI-CANCER AGENT: A REVIEW. Nidhi Sharma, Rupinder Kaur Gill, Anuradha Kaplish, Chander Mohan

FLAVONOIDS AS PROMISING ANTI-CANCER AGENT: A REVIEW.

Nidhi Sharma, Rupinder Kaur Gill, Anuradha Kaplish, Chander Mohan

International Journal of Natural Product Science 2012: Spl Issue 1:154.

Abstract(RBIP-154)

Flavonoids are widely distributed in the plant kingdom and exhibit broad pharmacological functions such as anticancer, anticarcinogenic, antiviral, antioxidant, antithrombogenic, and antiatherogenic activities. Flavonoid structure is based on a benzo-γ-pyrone (phenylchromone) nucleus or flavone nucleus. In recent years, flavonoids and their synthetic analogues have been intensely investigated in the treatment of ovarian, breast, cervical, pancreatic, and prostate cancer. Polymethoxylated flavones have been shown to reduce the invasiveness of tumors in animal models and to induce the differentiation of myeloid leukemic cells. The inhibitory effects of flavonoids on the growth of malignant cells could be a consequence of their interference with the protein kinase activities involved in the regulation of cellular proliferation and apoptosis. Flavonoids act as antioxidant by protecing cells against the damaging effects of reactive oxygen species, such as singlet oxygen, superoxide, peroxyl radicals, hydroxyl radicals and peroxynitrite. Flavonoids have the ability to act as reducing agents, making them capable of donating hydrogens to free radicals and causing their removal. Flavonoids can also act as singlet oxygen quenchers and as chelators of transition metals such as copper and iron, which are known pro-oxidants in foods. Other mechanisms of action have also been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis. Based on these results, flavonoids may be promising anticancer agents.
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