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FLAVONOID GLYCOSIDE FROM THE ROOTS OF STACHYS TIBETICA VATKE AND ITS EFFECT ON ANXIETY. Dinesh Kumar, Zulfiqar Ali Bhat, Vijender Kumar, M.Y Shah

FLAVONOID GLYCOSIDE FROM THE ROOTS OF STACHYS TIBETICA VATKE AND ITS EFFECT ON ANXIETY.

Dinesh Kumar, Zulfiqar Ali Bhat, Vijender Kumar, M.Y Shah

International Journal of Natural Product Science 2012: Spl Issue 1:136.

Abstract(RBIP-136)

Stachys tibetica (Lamiaceae) is an important medicinal plant in the folk medicine of Ladakh, India and Tibet for the treatment of various mental disorders. A flavonoid glycoside, Apigenin-7-glucoside (7-(beta-D-Glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) was isolated from the roots of stachys tibetica Vatke. Structure of this compound was determined by Co-TLC, melting point, chemical test and analyzing the spectroscopic data such as UV, IR, 1H NMR and FAB-MS studies. The compound was evaluated for its anxiolytic activity using elevated plus maze model and was found to produce statistically significant (*P < 0.05, **P < 0.01) anxiolytic activity in doses of 2.5 and 5 mg/kg body weight.

Keywords: Apigenin, Stachys tibetica Vatke, Flavonoid glycoside, Elevated plus maze, anxiolytics
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