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ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DALBERGIA SISSOO LEAVES EXTRACT. Jaspreet Kaur Sidana, Vipin Saini and Sumitra Dahiya

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DALBERGIA SISSOO LEAVES EXTRACT.

Jaspreet Kaur Sidana, Vipin Saini and Sumitra Dahiya

International Journal of Natural Product Science 2012: Spl Issue 1:134.


Abstract(RBIP-134)

Introduction- Inflammatory diseases included arthritis and rheumatism is major group of prevalent diseases. Dalbergia sissoo belonging to family Fabaceae, & subfamily Faboideae. Traditionally, oil of Dalbergia sissoo was used as a medicine for the management of pain and inflammation.

Methods- The purpose of this study was to evaluate the analgesic and anti-inflammatory properties of the methanolic extract of leaves of Dalbergia sissoo by using acetic acid induced writhing and hot plate tests (both in mice) and carrageenan- induced paw oedema in rats.

Results – Preliminary phytochemical screening of methanolic extract shows presence of tannins, aminoacid, flavonoids and carbohydrates. Oral pretreatment with the leaves extracts of Dalbergia sissoo significantly decreased the writhing movements in mice in acetic acid-induced writhing test and significantly increase the mean pain latency time in mice placed on the hot plate at 50°C at dose dependant manner. In the carrageenan-induced paw oedema model, the methanolic extract afforded 68.2% inhibition of hind paw oedema in rats at the highest dose (600 mg/kg) tested compared to 73.4% inhibition obtained with the reference drug, diclofenac (5 mg/kg) at the third hour after carrageenan administration.

Conclusion- These results indicate that the extract possesses both analgesic and anti-inflammatory properties.
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