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SYNTHESIS OF NOVEL CHROMONE BASED THIADIAZOLE DERIVATIVES. Richa K. Bhatia, Lakhwinder Singh, Ruchika Garg, Harinder singh

SYNTHESIS OF NOVEL CHROMONE BASED THIADIAZOLE DERIVATIVES.

Richa K. Bhatia, Lakhwinder Singh, Ruchika Garg, Harinder singh

International Journal of Natural Product Science 2012: Spl Issue 1:122.


Abstract(RBIP-122)

Chromone moeity display a wide range of biological activities like antifungal, antibacterial, anticancer, antihypoglycemic and antimalarial. Similarly, among different classes of heterocycles, thiadazoles have emerged as versatile framework and substituted thiadiazole possess variety of pharmacological properties including antibacterial. Presently, we have synthesize the 3-[(5-benzyl-1, 3, 4-thiadiazole-2-ylimino) methyl]-4H-chromen-4-one derivatives for their antibacterial activity. Thus, substituted 3-formylchromen-4-one was treated with 5-benzoyl-1, 3, 4-thiadiazole-2-amino to schiff base derivative in high yield and their antimicrobial testing is in progress.
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