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AN OVERVIEW OF RATIONAL DRUG DESIGN. Sonia Narwal, Reeta Rani Thakur

AN OVERVIEW OF RATIONAL DRUG DESIGN.

Sonia Narwal, Reeta Rani Thakur

International Journal of Natural Product Science 2012: Spl Issue 1:116.


Abstract(RBIP-116)

Rational drug design is also sometimes referred as Drug design or Rational design. It is a process in which finding of new medication based on knowledge of biological target is done. It involves design of small molecules that are complementary in shape and charge to bimolecular target. There are two types of drug design First one is ligand based drug design and second is structure based drug design. Ligand based drug design is also called as indirect drug design. It depends upon knowledge of other molecules that binds to biological target of intrest.These other molecules may be used to derive a pharmacophore model to design the minimum necessary structural characteristics. Structure based drug design depends upon knowledge of three dimensional structure of bimolecular target. It is also called as direct drug design. If experimental structure of target is not available, it may be possible to create a homology model of target. The first example of application of structure based drug design leads to carbonic anhydrase inhibitor Dorzolamide approved in 1995.Mostly drugs are organic small molecules produced by chemical synthesis. In addition, mRNA-Based gene silencing technologies may have theuraptic applications. An example of rational drug design is use of three dimensional information about bimolecules obtained from NMR Spectroscopy and X-ray Crystallography techniques. In rational drug design, an important case study is tyrosine kinase inhibitor Imatinib designed specifically for the bcr-abl fusion protein. Many of the atypical antipsychotics are other examples of rational drug design.
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