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ANTI-CANCER ACTIVITIES OF VARIOUS HETEROCYCLIC CONTAINING ENTITES - A REVIEW. Gurvinder Kaur and Rakesh Yadav

ANTI-CANCER ACTIVITIES OF VARIOUS HETEROCYCLIC CONTAINING ENTITES - A REVIEW.

Gurvinder Kaur and Rakesh Yadav

International Journal of Natural Product Science 2012: Spl Issue 1:104.

Abstract(RBIP-104)

The uncontrolled growth of cells in the body, started due to certain stimuli, lays the foundation of cancer. Anticancer drugs either kill cancer cells or modify their growth. Cancer or neoplastic disease may be regarded as a family of related disorders. A common feature in different forms of cancer is an abnormal and uncontrolled cell division, frequently at a rate greater than that of most normal body cells. Among the heterocyclic compounds, five membered heterocyclic moieties fused with aromatic ring system with various heteroatoms like N, S, and O have possess wide spectrum of pharmacological activity. Synthesis of nitrogen containing heterocyclic compounds has been a subject of great interest due to the wide application in agrochemical and pharmaceutical fields. Heterocycles like indole, pyrimidine, pyridine, quinoline, etc. are an integral part of a huge number of natural and synthetic compounds and play important roles in the biological systems. For developing the suitable leads for anti-cancer drugs introduction of appropriate substituents at C-3 of indole, C-5 of pyrimidine, C-2 of pyridine and quinoline is required. The substituent carries nitrogen and oxygen as two ligating sites along with hydrophobic moieties, the essential requirement for multiple target ligands. The structure–activity relationship studies point that the contribution of phenylglycinol moiety as a part of side chain at C-3 of indole and C-5 of pyrimidine seems to be crucial for exhibiting anti-cancer activities.
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