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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF ATORVASTATIN CALCIUM. Tania Munjal, Neelam Singh, Sukhbir Singh, Sandeep Arora

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF ATORVASTATIN CALCIUM.

Tania Munjal, Neelam Singh, Sukhbir Singh, Sandeep Arora

International Journal of Natural Product Science 2012: Spl Issue 1:97.

Abstract (RBIP-97)

Microspheres are one of the multiparticulate delivery systems and are prepared to obtain prolonged or controlled drug delivery, to improve bioavailability or stability, reducing side effects and improving patient compliance. A w/o/w emulsion solvent evaporation method was employed for the preparation of Atorvastatin Calcium Microspheres containing Eudragit RL 100 and Eudragit RS 100. The influence of formulation factors (polymer: drug ratio, emulsifier concentration, viscosity of aqueous phase, stirring speed and stirring time) on particle size, morphology, encapsulation efficiency, drug loading, process yield and in vitro release behavior was studied. The in-vitro performances of microspheres were evaluated by recovery efficiency, particle size analysis, surface topography (using scanning electron microscopy), drug-polymer compatibility (FTIR) and drug release studies. The w/o/w emulsion solvent evaporation method was suitable for the preparation of microspheres in the size range of 101.75 ± 0.82 μm, the encapsulation efficiency was 74.879 ± 1.23% (w/w) and the process yield was 87.65 ± 1.89% (w/w). SEM revealed that micro particles were smooth, spherical in shape. FTIR studies showed no potential chemical interaction between the drug and polymer used. In vitro release studies revealed a controlled release of microspheres suitable for peroral administration. Drug release from microspheres followed Higuchi kinetics.
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