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DIFFERENTLY SHAPED POLYMERIC NANOSTRUCTURES- ENHANCED DRUG DELIVERY OUTCOMES. Ankit Rampal

DIFFERENTLY SHAPED POLYMERIC NANOSTRUCTURES- ENHANCED DRUG DELIVERY OUTCOMES.

Ankit Rampal

International Journal of Natural Product Science 2012: Spl Issue 1:96.

Abstract (RBIP-96)

Possibility of tailoring the shape of the nanostructures has allowed for the fabrication of model systems with chemically equivalent but topologically different carriers. Evaluation of the importance of particle shape in the context of biodistribution, cellular uptake and toxicity has become a major thrust area. The preparation of nanostructures of different shape is classified into the topdown and bottom-up approaches. The top-down approaches have opened up the possibilities especially in the sub-micron range, providing access to the range of shapes and having practically mono-disperse and reproducible nanostructures at will. Bioinspired bottom-up approaches offer unprecedented advantages as with these methods one can not only reliably assemble but also enable programmed dis-assembly of nanostructures. Non-spherical particles prolong blood circulation time, display different in vivo distribution profiles from their spherical counterparts, providing means for targeting to specific organs and also tumour tissues. Shape effects on cellular internalization are a pertinent theme in drug delivery as therapeutic-carrying nanoparticles require internalization into cells via endocytosis. Shape has shown to affect cell viabilities and inflammatory responses to different extents.
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