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TRANSDERMAL PERMEATION OF ANTIHYPERTENSIVE DRUGS USING NANOEMULSION. Kushal, Chaudhary H, Garg A.

TRANSDERMAL PERMEATION OF ANTIHYPERTENSIVE DRUGS USING NANOEMULSION.

Kushal, Chaudhary H, Garg A.

International Journal of Natural Product Science 2012: Spl Issue 1:83.

Abstract (RBIP-83)

Transdermal Drug Delivery Systems (TDDS) are one of the most rapidly advancing areas of novel drug delivery, which are designed to deliver a therapeutically effective amount of drug across skin. Nanoemulsion are fine oil/water or water/oil dispersion stabilized by an interfacial film of surfactant molecules having droplet covering the size range 20-600nm There are two pathways tansappendageal and intercellular pathway by which drug can cross the skin and reach the systemic circulation. Due to small droplet size range nanoemulsion are able to penetrate easily through the skin layers and enhance skin penetration of incorporated drugs in TDDS. It enhances the drug permeation through the skin which can be achieved by using chemical enhancers and various solvents. Use of chemical enhancers is limited for its chronic application as it causes irritation at the site of application. It is therefore desirable to develop a topical vehicle instead of chemical enhancers for formulating transdermal drug delivery system. Nanoemulsion technique proved to be one of the most promising techniques for enhancement of transdermal permeation of drugs. Hypertension is a chronic disease which required lifelong therapy. But most of antihypertensive drugs available today, showed extensive first-pass metabolism and low oral bioavailability which can be overcome by preparing its Transdermal Drug Delivery Systems.
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