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INVESTIGATION OF PROBLEMS FACED DURING FORMULATION OF MICROSPHERES FOR SCALE-UP. Tejasvi Gaur, Purnima Verma, Sachin Kumar Singh

INVESTIGATION OF PROBLEMS FACED DURING FORMULATION OF MICROSPHERES FOR SCALE-UP.

Tejasvi Gaur, Purnima Verma, Sachin Kumar Singh

International Journal of Natural Product Science 2012: Spl Issue 1:82.

Abstract (RBIP-82)

Microsphere carrier systems made from the naturally occurring biodegradable polymers have attracted considerable attention for the last several years in sustained drug delivery. Recently, dosage forms that can precisely control the release rates and target drugs to a specific body site have created enormous impact in formulation and development of the novel drug delivery systems. Microspheres are an important part of such novel drug delivery systems. They have various applications and are prepared by using different polymers. However, the success of these microspheres is limited due to their short residence time at the site of absorption. It would, therefore be advantageous to have means to provide an intimate contact of the drug delivery system with the absorbing membranes. Various techniques have been utilized for the preparation of microspheres but while considering scale-up factors certain points have to be considered such as critical steps involved, time consumed, use of organic reagents. Processes involved such as single/double emulsion, Coacervation phase separation and spray drying techniques have various advantages, but they lack stability and drug loading capacity as well as disadvantages but while considering scale-up various factors have to be considered such as time consumed for formulation of single batch, process factors involving drying time emulsification process all are considered because of per batch capital is involved thus presented article deals with study of formulation of microspheres in order to differentiate problems faced during lab scale as well as for checking out the robustness of the lab process in accordance with scale-up for commercial use.
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