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SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS): AN ALTERNATIVE APPROACH FOR HYDROPHOBIC DRUGS. Pooja Mittal, Nimrata Seth, A C Rana

SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS): AN ALTERNATIVE APPROACH FOR HYDROPHOBIC DRUGS.

Pooja Mittal, Nimrata Seth, A C Rana

International Journal of Natural Product Science 2012: Spl Issue 1:80.

Abstract (RBIP-80)

The delivery of poorly water-soluble drugs has been the subject of much research, as approximately 40% of new chemical entities are hydrophobic in nature and therefore have low and erratic bioavailability profile which leads to high inter and intra subject variability, lack of dose proportionality and therapeutic failure. Among the various approaches like micronization, solid dispersions, cyclodextrin complex , Self micro emulsifying drug delivery system has gained more attention due to enhanced oral bioavailability enabling reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drugs towards specific absorption window in G.I.T and protection from the hostile environment in gut. These Lipid formulations for oral administration of drugs generally consist of a drug dissolved in a blend of two or more excipients, which may be triglyceride oils, partial glycerides, surfactants or co-surfactants. The primary mechanism of action which leads to improved bioavailability is usually avoidance, or partial avoidance, of the slow dissolution process which limits the bioavailability of hydrophobic drugs from solid dosage forms. Ideally the formulation allows the drug to remain in a dissolved state throughout its transit through the gastrointestinal tract. The digestive motility of the stomach and intestine provide the agitation necessary for self emulsification in vivo. This review describes about the formulation methodology, evaluation parameters and the future aspects of SMEDDS.

Key Words- Self Microemulsifying drug delivery Systems, Bioavailability, Dissolution
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