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PULSATILE DRUG DELIVERY SYSTEM: RECENT TECHNOLOGY. Sunita

PULSATILE DRUG DELIVERY SYSTEM: RECENT TECHNOLOGY.

Sunita

International Journal of Natural Product Science 2012: Spl Issue 1:79.

Abstract (RBIP-79)

Pulsatile drug delivery system (PDDS) is gaining a lot of interest as they deliver the drug at right site of action at the right time and in the right amount. Thus providing spatial and temporal delivery and deliver the patient compliance. These systems are designed according to the circadian rhythm of the body, and the drug is released rapidly and completely as a pulse after a lag time. Products follow the sigmoid release profile characterized by a time period. Theses follow chronopharmacological behavior, where nocturnal dosing is required, and for drugs that show the first-pass effect. In recent pharmaceutical application involving pulsatile delivery, multiparticulate dosage forms are gaining much favour over single unit dosage forms because of their potential benefit like predictable gastric empting, no risk of dose dumping, flexible release pattern and increased bioavailability .Various systems like capsular system, osmotic system, and single multiple unit system based on the use of soluble or erodible polymer coating and use of repturable membrane. The various technologies formulate parameter and release profile of these system. Marketed technologies, such as PulsincapTM, Diffucaps®, CODAS®, OROS® and PULSYSTM, follow the above mechanism to render a sigmoidal drug release profile. Diseases where in PDDS are promising include asthma, peptic ulcers, cardiovascular ailments, arthritis and attention deficit syndrome in children and hypercholesterolemia.
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