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DRUG DELIVERY ACROSS HUMAN NAIL FOR TREATMENT OF FUNGAL DISEASE Sunil Kumar, Amardeep Hooda, Rekha Valecha

DRUG DELIVERY ACROSS HUMAN NAIL FOR TREATMENT OF FUNGAL DISEASE

Sunil Kumar, Amardeep Hooda, Rekha Valecha

International Journal of Natural Product Science 2012: Spl Issue 1:74.

Abstract (RBIP-74)

Topical nail preparations like lacquers, enamel, and varnish are an integral part of today’s beauty treatments. It protects the nail plate. The basic nail varnish consists of solvents, film forming polymers, resins which enable the film to adhere to nail plate and convey shining to the film, plasticizers which gives flexibility and durability to the film, coloring agents and suspending agents. In recent years, medicated nail lacquers specially designed for the nail diseases, strike the formulation field. Nail diseases like oncomycosis, nail psoriasis, yellow nail syndrome, paronychia and many more, being cured successfully using medicated nail lacquers. This avoids the oral toxicity of antifungal drugs and provides longer contact time at the site of action. Targeting drug treatment to fungal infections that reside within or below the nail plate is problematic due to the highly restrictive barrier of the human nail .Some techniques used to enhance the topical bioavailability of the drugs across the nail is a latest trend in drug delivery across the nail .This systemic review covers the anatomy of a human nail, diseases related to nail plate, the formulations designed for nail application and some techniques used to enhance the topical bioavailability of the drugs across the nail and latest trends in drug delivery across the nail.
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