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NANOCARRIERS AS AN EMERGING PLATFORM FOR CANCER THERAPY. Sunil Kamboj, Suman Bala, Anroop B. Nair, Vipin Saini

NANOCARRIERS AS AN EMERGING PLATFORM FOR CANCER THERAPY.

Sunil Kamboj, Suman Bala, Anroop B. Nair, Vipin Saini


International Journal of Natural Product Science 2012: Spl Issue 1:71.

Abstract (RBIP-71)

Cancer remains one of the world’s most devastating diseases, with more than 10 million new cases every year. Current cancer treatments include surgical intervention, radiation and chemotherapeutic drugs, which often also kill healthy cells and cause toxicity to the patient. It would therefore be desirable to develop chemotherapeutics that can either passively or actively target cancerous cells. Passive targeting exploits the characteristic features of tumour biology that allow nanocarriers to accumulate in the tumour by the enhanced permeability and retention (EPR) effect. Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Nanocarriers are nanosized materials (diameter 1–100 nm) that can carry multiple drugs and/or imaging agents. Nanocarriers encounter numerous barriers en route to their target, such as mucosal barriers and non-specific uptake. To address the challenges of targeting tumours with nanotechnology, it is necessary to combine the rational design of nanocarriers with the fundamental understanding of tumour biology. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients. Owing to their high surface area to-volume ratio, it is possible to achieve high ligand density on the surface for targeting purposes. Nanocarriers can also be used to increase local drug concentration by carrying the drug within and control-releasing it when bound to the targets.
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