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AN APPROACH TO TREAT LUNG CANCER BY BREAKING THE “MUCUS BARRIER” Suchitra, Rakhi, Sharma Swati, Kapoor Gunjan, Malhotra Ritika, Khatri Naveen, Seth Mamta

AN APPROACH TO TREAT LUNG CANCER BY BREAKING THE “MUCUS BARRIER”

Suchitra, Rakhi, Sharma Swati, Kapoor Gunjan, Malhotra Ritika, Khatri Naveen, Seth Mamta

International Journal of Natural Product Science 2012: Spl Issue 1:70.


Abstract (RBIP-70)

Protective mucus coating typically traps and rapidly removes foreign particles thereby strongly limiting opportunities for controlled drug delivery at mucosal surfaces. To avoid rapid clearance and achieve high local drug dosages that can be sustained over time, biodegradable nanoparticle are formulated. These are capable of penetrating highly viscoelastic human mucus secretions. Transport of nanoparticle in mucus is made possible by the efficient partitioning of PEG to the particle surface during formulation. Densely coated non-biodegradable latex particles with PEG, a hydrophilic and uncharged molecule, effectively minimizes adhesive interactions between nanoparticles and mucins allowing nanoparticles to rapidly penetrate highly viscoelastic human mucus by moving through openings between mucin mesh fibers. Thus the polymeric nanoparticle helps in sustained and effective delivery of drugs and genes.
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