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COMPARISON OF NOVEL VESICULAR SYSTEM (TRANSFEROSOMES, NIOSOMES) FOR TRANSDERMAL DRUG DELIVERY. Ravi Kumar, Manvir Singh, Rajni Bala, Nimrata Seth, A C Rana

COMPARISON OF NOVEL VESICULAR SYSTEM (TRANSFEROSOMES, NIOSOMES) FOR TRANSDERMAL DRUG DELIVERY.

Ravi Kumar, Manvir Singh, Rajni Bala, Nimrata Seth, A C Rana


International Journal of Natural Product Science 2012: Spl Issue 1:64.

Abstract (RBIP-64)

Transdermal drug delivery system appears to be most promising delivery system due to their merits over conventional delivery systems. Recently, various strategies have been used to augment the transdermal delivery of bioactives. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system (liposomes, niosomes, transfersomes). Among these strategies transferosomes appear promising. Transfersomes possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. Niosomes may be defined as unilamellar or multilamellar vesicles where in an aqueous solution is enclosed in highly ordered bilayer made up of non-ionic surfactant with or without cholesterol and diacetylphosphate. Transferosomes and niosomes are prepared by thin film hydration technique and sonication. The systems can be characterized by in vitro for vesicle shape and size distribution, entrapment efficiency, degree of deformability, number of vesicles per cubic mm. Transferosomes have beneficial advantages over other vesicular systems such as their high penetration power across skin, higher stability, systemic drug release possible and higher deformability than other vesicular systems such as niosomes, ethosomes etc. But niosomes have some advantages that they can better utilize for drug targeting, ease of handling.

Keywords: Transferosomes, Niosomes
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