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IONTOPHORETIC DELIVERY OF CICLOPIROX OLAMINE Jyoti Wadhwa, Anroop Nair, Saloni Kakkar

IONTOPHORETIC DELIVERY OF CICLOPIROX OLAMINE

Jyoti Wadhwa, Anroop Nair, Saloni Kakkar

International Journal of Natural Product Science 2012: Spl Issue 1:58.

Abstract (RBIP-58)

The success of topical nail therapy primarily depends upon the capability of the technique to transport the antimycotics into and through the nail plate. Current treatment options for onychomycosis are suboptimal due to the poor penetration of drug in the affected area. The objective of present study was to assess the feasibility of constant low voltage iontophoresis for the transungual delivery using a model potent antifungal agent, ciclopirox olamine. Initial studies revealed that application of constant voltage iontophoresis enhanced the permeation by an order of magnitude (P=0.019) and delivered significant amount of drug into the deeper nail layers. Results of on off studies and step-up/step-down studies substantiated the viability of the current technique. Excellent correlation was observed in permeation (r2=0.98) and drug load (r2=0.97) with the increase in applied voltage (3-12V), indicating that the current technique is predictable. Given the excellent results, the current technique could be used as an effective approach for the delivery of antimycotics, which would localize the drug at the infection site and potentially offer higher patient compliance.
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