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SOLID - SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM – A MERGE FORM OF SMEDDS AND SOLID DOSAGE FORM. Sood Suman, Kumar Vipin, Rana A C, Singh Gurpreet

SOLID - SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM – A MERGE FORM OF SMEDDS AND SOLID DOSAGE FORM.

Sood Suman, Kumar Vipin, Rana A C, Singh Gurpreet

International Journal of Natural Product Science 2012: Spl Issue 1:42.

Abstract (RBIP-42)

Self-Microemulsifying Drug Delivery Systems (SMEDDS) are isotropic mixtures of oil, surfactant or cosurfactants, and a drug that forms an oil-in-water nanoemulsion with water. SMEDDS usually, limited to liquid dosage forms, because many excipients used in SMEDDS are not solids at room temperature. Given the advantages of solid dosage forms, Solid-SMEDDS represent more effective alternatives to conventional liquid SMEDDS. Purpose of this study is to develop Solid-SMEDDS(S-SMEDDS) which provide characteristics of both SMEDDS as well as solid dosage form (e.g. excipients selection, specificity, characterization). From the perspective of dosage forms, S-SMEDDS mean solid dosage forms with self-emulsification properties. S-SMEDDS is formulated by incorporating liquid/semisolid SE ingredients into powders/ nanoparticles by different solidification techniques. S-SMEDDS are combinations of SMEDDS and solid dosage forms, therefore characterizations of S-SMEDDS contain not only the assessment of self-emulsification, but also friability, surface roughness. Thus, S-SMEDDS combine the advantages of SMEEDS with those of solid dosage form e.g. low production cost, convenience of process control, high stability and better patient compliance. Solid state characterization of S-SMEDDS is performed using SEM, DSC and powder x-ray diffractometry.

Keywords: SMEDDS; Solid; SEM; DSC
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