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PULMONARY DRUG DELIVERY USING LARGE, POROUS-HOLLOW INHALED PARTICLES. Suraj Dwivedi, Arjun Nanda, Sweety, Jatinderjot Kehal, Dr. Chander Mohan

PULMONARY DRUG DELIVERY USING LARGE, POROUS-HOLLOW INHALED PARTICLES

Suraj Dwivedi, Arjun Nanda, Sweety, Jatinderjot Kehal, Dr. Chander Mohan

International Journal of Natural Product Science 2012: Spl Issue 1:35.

Abstract (RBIP-35)

The ability to deliver drugs to the systemic circulation by inhalation has contributed to a rise in the number of inhalation therapies under investigation. For most of these therapies, aerosols are designed to comprise small spherical droplets or particles of mass density near 1 g/cm3 and mean geometric diameter between ∼1 and 3 μm, suitable for particle penetration into the airways/lung periphery. These characteristics of inhaled aerosols lead to optimal therapeutic effect, both for local and systemic therapeutic delivery. Inefficient drug delivery can still arise, owing to excessive particle aggregation in an inhaler, deposition in the mouth and throat, and overly rapid particle removal from the lungs by phagocytic clearance mechanisms. The major improvements in aerosol particle performance may also be achieved by lowering particle mass density and increasing particle size, since large, porous particles display less tendency to agglomerate than small and nonporous particles. Also, large porous particles inhaled into the lungs can potentially release therapeutic substances for long periods of time by escaping phagocytic clearance from the lung periphery, thus enabling therapeutic action for periods ranging from hours to many days. The present study shows the feasibility of innovative drug delivery system.
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