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PHARMACOSOMES: AN ALTERNATIVE CARRIER FOR DRUG DELIVERY. Poonamdeep kaur, Dinesh Kumar, H. S. Rao, Rishu Kakkar, Pooja Sharma

PHARMACOSOMES: AN ALTERNATIVE CARRIER FOR DRUG DELIVERY.

Poonamdeep kaur, Dinesh Kumar, H. S. Rao, Rishu Kakkar, Pooja Sharma

International Journal of Natural Product Science 2012: Spl Issue 1:32.

Abstract (RBIP-32)

Various types of vesicular systems such as liposomes, noisome, transfersomes and pharmacosomes have been developed in the transport and targeting of active agents. Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids, and may exist as ultrafine vesicular, Micelles, or hexagonal aggregates, depending on the chemical structure of drug-lipid complex. This system shows low entrapment efficiency and drug leakage during storage for hydrophilic drugs. Pharmacosomes have some importance in escaping the tedious steps of removing the free from entrapped drug. Similar to other vesicular system pharmacosomes provide an efficient method for delivery of drug directly to the site of infection, leading to reduction of drug toxicity with no adverse effects also reduces the cost of therapy by improved bioavailability of medication, especially in case of poorly soluble drugs. Pharmacosomes are suitable for incorporating both hydrophilic and lipophilic drugs. Pharmacosomes are amphiphilic lipid vesicular systems containing phospholipids complexes with a potential to improve bioavailability of poorly water soluble as well as poorly lipophilic drugs. The pharmacosomes may be developed for adding the biopharmaceutical values (like solubility, permeability). Pharmacosomes are like a panacea for most of the problems associated with liposomes, transferosomes, noisome, and so forth. They are an efficient tool to achieve desired therapeutic goals such as drug targeting and controlled release.
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