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BRAIN TARGETING THROUGH NASAL ROUTE: THE ROYAL ROAD TO IMPROVE CENTRAL NERVOUS SYSTEM DISORDERS Sharma Swati, Suchitra, Rakhi, Seth M

BRAIN TARGETING THROUGH NASAL ROUTE: THE ROYAL ROAD TO IMPROVE CENTRAL NERVOUS SYSTEM DISORDERS.

Sharma Swati, Suchitra, Rakhi, Seth M

International Journal of Natural Product Science 2012: Spl Issue 1:28.

Abstract (RBIP-28)

Blood brain barrier limits the entry of drugs and this makes the CNS treatment ineffective. Nose to brain drug delivery can revolutionize the treatment of brain disorders. The olfactory region, next to respiratory region is the foremost site from where drug can be absorbed directly into the brain by different mechanisms including transcellular, paracellular, olfactory(front of the brain) and trigeminal(back of the brain) neural pathways. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provide a direct connection between brain and external environment. Intranasal delivery avoids gut and liver first pass metabolism so the drugs which get metabolised in GIT can be easily given by this route. The major challenges to this delivery are to achieve maximum absorption by efficiently targeting and retaining the formulation in the olfactory region. Drug can be targeted with the help of nanostructured lipid carrier, pressurized olfactory device, mucoadhesive microemulsions. Intranasal delivery seems to be the most promising application form to improve CNS disorders including brain injuries.
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