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TASTE MASKING OF BITTER DRUG: AN OVERVIEW. Moni Ranaut, A.C.Rana, Nimarata Seth, Reena Sharma

TASTE MASKING OF BITTER DRUG: AN OVERVIEW.

Moni Ranaut, A.C.Rana, Nimarata Seth, Reena Sharma

International Journal of Natural Product Science 2012: Spl Issue 1:23.

Abstract (RBIP-23)

Taste is most important organoleptic aspects about the acceptance of oral drugs. Bitter and unpalatable taste is a major problem of certain drugs in formulations. In market, there are numbers of pharmaceutical preparations available in which actives are bitter in taste. The bitterness of preparation also leads to patient incompliance. So masking of bitterness becomes essential and done by masking the bitter taste of drugs by either decreasing its oral solubility on ingestion. The factors critical to the selection of an taste masking technique such as solubility, particle characteristics, dosage form and dose. Orally disintegrating tablets offer great advantages for patients having difficulty in swallowing. The unique property of mouth dissolving tablet is that they are rapidly disintegrating and dissolving and release the drug as soon as they come in contact with saliva. Methods commonly used for taste masking involves various physical and chemical method that prevent the interaction of taste bud with drugs and are based on coatings, solid dispersion system and ion exchange resin, entrapment method and masking of taste buds etc.

Keywords: Taste masking, oral disintegrating tablet, Mouth dissolving tablet, Bitter.
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