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PULSED DRUG DELIVERY SYSTEM: CURRENT SCENARIO. Hitesh Chopra, Punam Gaba

PULSED DRUG DELIVERY SYSTEM: CURRENT SCENARIO.

Hitesh Chopra, Punam Gaba

International Journal of Natural Product Science 2012: Spl Issue 1:18.


Abstract (RBIP-18)

Modified release dosage forms have acquired a great importance in the current pharmaceutical R&D business. Such systems offer control over the release pattern of drug and provide better control over drug regimen. Such systems release the drug with predetermined release rates, either constant or variable. These dosage forms offer numerous advantages, such as nearly stable plasma drug level without many fluctuations, reduction in dose of drug, reduced dosage frequency, least side effects, and improved patient compliance. Pulsatile system is amongst one of them and gaining a lot of interest as it is increasing patient compliance by means of providing time- and site-specific drug delivery system, thus providing special and temporal delivery. Pulsed or pulsatile drug release is defined as the rapid and transient release of a certain amount of drug molecules within a short time-period immediately after a predetermined off-release period. Recent studies show that diseased have predictable cyclic rhythms and the timing of medication regimens can improve outcome in selected chronic conditions.
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