HIGH QUALITY SCIENTIFIC CONTENT,  ONLINE OPEN ACCESS,  GLOBAL SCIENTIFIC AUDIENCE,  COST EFFECTIVE, ANY ONE CAN DOWNLOAD REPRINTS 
Spreading knowledge

Google Scholar

Google Scholar

Archives

Back 

PHARMACOSOMES – TARGETED DRUG DELIVERY SYSTEM. Harpreet Kaur, A.C. Rana, Nimarata Seth, Amandeep Kaur

PHARMACOSOMES – TARGETED DRUG DELIVERY SYSTEM.

Harpreet Kaur, A.C. Rana, Nimarata Seth, Amandeep Kaur

International Journal of Natural Product Science 2012: Spl Issue 1:17. .

Abstract (RBIP-17)

Various types of lipid based vesicular system have been developed in controlled and targeted drug delivery. Pharmacosomes bearing unique advantage over liposomes and niosomes have come up as potential alternative to conventional vesicles. Pharmacosomes are amphiphilic phospholipid complexes of drugs bearing active hydrogen that binds to phospholipids. As the system is formed by combining drug (pharmakon) to carrier(soma), they are termed as pharmacosomes. Depending upon the chemical structure of the drug lipid complex they may exist in ultrafine vesicular, micellar and hexagonal aggregate. Any drug having an active hydrogen group(-COOH,-OH etc) can be esterified to lipids, resulting in amphiphillic compound. In general two methods have been employed to prepare pharmacosomes. These are hand shaking method and ether injection method. Developing the pharmacosomes of the drug has been found to improve the absorption and minimize the gastro-intestinal toxicity. Pharmacosomes have been prepared for various non-steroidal anti-inflammatory drugs, proteins, cardiovascular and antineoplastic drug. The drug is released from pharmacosome by hydrolysis (including enzymatic).

Keywords: Pharmacosomes, Amphiphilic, targeted drug delivery system, etc.
Attachments:
Time to create page: 0.12 seconds


Copyright © All rights reserved Science Instinct Publications sciipub.com