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GLUCOSAMINE HCL TIMED RELEASE TABLETS: A BOON FOR OSTEOARTHRITIS PATIENTS. Deepak Kumar Khanna, Manoj Kumar Katual

GLUCOSAMINE HCL TIMED RELEASE TABLETS: A BOON FOR OSTEOARTHRITIS PATIENTS.

Deepak Kumar Khanna, Manoj Kumar Katual

International Journal of Natural Product Science 2012: Spl Issue 1:16.

Abstract (RBIP-16)

Most of the conventional drug delivery system for treating the osteoarthritis are not much effective as the drug do not reach the site of action in appropriate concentration. Thus an effective and safe therapy of this osteoarthritis disorder using specific drug delivery system is a challenging task to the pharmaceutical technologists. The dietary supplements glucosamine HCl appeared better response in slowing loss of cartilage in osteoarthritis of the knee .Glucosamine (C6H13NO5) is an amino sugar and is needed in the making of glycosylated proteins and lipids like the cartilage found in the joints. Glucosamine is one of the most common monosaccharides.1500mg of Glucosamine HCl is the therapeutic daily dose used for joint pain relief (having the half life less than 1 hr) which leads to dose frequency subsequently patient non-compliance. The objective of the present study was to develop glucosamine timed release tablet which can release the drug up to time of 12 hrs in predetermined rate. The formulation of glucosamine timed release tablet was prepared by the polymer combination in order to get required theoretical release profile. The influence of hydrophilic (HPMC) and hydrophobic (EC) polymer and granulation technique on glucosamine was studied. The formulated tablets were also characterized by physical and chemical parameters. The in–vitro release rate profile data was satisfactory.
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