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EMULSOMES: A EMERGING VESICULAR DRUG DELIVERY SYSTEM. Jatinder Singh, Vikas Sharma, Bhawandeep Gill, S L Hari Kumar

EMULSOMES: A EMERGING VESICULAR DRUG DELIVERY SYSTEM

Jatinder Singh, Vikas Sharma, Bhawandeep Gill, S L Hari Kumar
International Journal of Natural Product Science 2012: Spl Issue 1:14.

Abstract(RBIP-14)

The oral route is the easiest, cost effective and most vital method for drug administration. Therefore, improvement of dosage forms mainly for the prolonged release purpose has been a challenge for scientists. Vesicular drug delivery systems are developed with a purpose to overcome problems coupled with the drugs such a poor bioavailability, protection from harsh gastric environment and from gastric enzymes. Vesicular drug delivery systems such as liposomes, emulsions, niosomes, proniosomes, ethosomes, and pharmacosomes etc have gained much attention but, Emulsomes have rouse as system which bypasses many disadvantages associated with other systems, developed as novel lipoidal vesicular system with internal solid fat core surrounded by phospholipid bilayer. This technology is designed to act as vehicle for poorly soluble drugs. The drug is enclosed in the Emulsomes, provide prolong existence of drug in systemic circulation. Furthermore, Emulsomal-based formulations of genetic drugs such as antisense oligonucleotides and plasmids for gene therapy that have clear potential for systemic utility are increasingly available. This review addresses the concept of emulsomal drug delivery system, summarizes the success of emulsomes for the delivery of small molecules and special attention has been paid to its formulation design, advantages, stability aspects and various aspects related to drug delivery.
Key words: Emulsomes, Vesicular drug delivery, Controlled oral drug delivery, Oral Bioavailability.


Keywords: Acetyl-L-carnitine, Hemodynamic function, Ischemia, Myocardial infarction, Rat, Reperfusion
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