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A BRIEF REVIEW ON “SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS”. Monika, Vikramjit Singh, Nawazish Alam.

A BRIEF REVIEW ON “SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS”.

Monika, Vikramjit Singh, Nawazish Alam.

International Journal of Natural Product Science 2012: Spl Issue 1: 6.

Abstract (RBIP-06)

Among all newly discovered chemical entities about 40%drugs are lipophilic and fail to reach market due to their poor water solubility .The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. With the advent of combinatorial chemistry and a high throughput screening, the number of poorly water soluble compounds has increased solubility. A success of formulation depends on how efficiently it makes the drug available at the site of action .Therapeutic effectiveness of a drug depends on the bioavailability and ultimately upon the solubility of drug molecules especially in oral formulation. Poorly water soluble drugs after oral administration often require high dose in order to reach therapeutic concentration .The bioavailability of an orally administration drug depends on its solubility in aqueous media over different pH ranges. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds .Various techniques are used for the improvement of aqueous solubility ,dissolution rate, and bioavailability of poorly water soluble drugs include micronization ,chemical modification ,pH adjustment ,solid dispersion , complexation , co-solvency, micellar solubilization, hydrotrophy etc. The purpose of this review article is to describe the techniques of solubilization for the attainment of effective absorption with improved bioavailability.

Keywords: Solubilty, bioavailabilty, solid dispersion, micronization.
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